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Interestingly, some drugs are not completely metabolized or some metabolites are still excreted in the original form after many complex steps (Molet et al., 1997), activation ( FIGURE 1 Phase I metabolism pathway A series of reactions of most drugs occurs under the specific enzymes catalyze, which lead to structure and physicochemical properties changed (Iyanagi, 2007)

10.1164/rccm.201810-1975TR 6 BirchJ.JessG

It says most berberine studies involve small sample sizes of roughly 30 to 100 participants and short durations of 8 to 12 weeks

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Archives of Internal Medicine , 162 (8), 893.